003). FCGR3B copy number assignment based on FCGR3B:CD36 ratios revealed significant skewing in the distribution of FCGR3B copy number between IPF patients and controls. In the IPF cohort, there was increased frequency of
> MK-2206 ic50 2 FCGR3B copies compared to controls (0.30 vs. 0.19; chi(2) = 9.27; d.f. 2; p = 0.0097). The presence of > 2 FCGR3B copies was associated with higher risk of IPF (p = 0.01, OR: 1.914, 95% CI: 1.17-3.12). Conclusions: These findings support an association of FCGR3B copy number with susceptibility to IPF and propose a novel role for Fc gamma receptors in IPF disease pathogenesis. Copyright (C) 2010 S. Karger AG, Basel”
“Objectives: Mannose-binding lectin and macrophage migration inhibitory factor gene polymorphisms are associated with several acute/chronic autoimmune or inflammatory diseases. The aim of this study was to investigate if there was any association between mannose-binding lectin 2 (MBL2) and macrophage migration MX69 research buy inhibitory factor (MIF) gene polymorphisms and profound congenital sensorineural hearing loss in children who underwent cochlear implantation.
Methods: A total of 62 patients with congenital hearing loss and 80 age- and sex-matched healthy controls were evaluated for codon 54 A/B polymorphisms in MBL2 and the-173 G/C polymorphism in MIF by using the polymerase chain
reaction and restriction fragment length polymorphism method.
Results: The frequency of the BB genotype of MBL2 and MIF – 173 GC genotype were statistically significantly higher in the patient group than in the controls (p = 0.0127, p = 0.0408, respectively).
Conclusion: In this study, we found that a subject who is homozygous for the variant allele B of codon 54 of the MBL2 and heterozygous for variant selleck kinase inhibitor allele C of – 173 MIF has a risk factor for sensorineural hearing loss. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Objective: A prospective study was carried out to determine the sensitivity and specificity of reflux symptoms
and laryngeal findings to diagnose laryngopharyngeal reflux (LPR) and gastro-esophageal reflux (GER) in children with asthma by comparing the results of double probe pH monitorization and to determine the difference between controlled and uncontrolled asthma in terms of GER and LPR coexistence.
Methods: A total of 50 patients (23 girls, mean age 10.8 +/- 0.4 years) with mild to moderate persistent asthma were included in this study. The patients were divided in two groups according to the asthma control status as controlled (n = 27) vs. uncontrolled asthma (n = 23). All patients completed the reflux symptom questionnaire and then they underwent flexible fiberoptic laryngoscopy and 24 h double probe (pharyngeal and esophageal) pH monitorization. Laryngopharyngeal and gastroesophageal reflux were defined according to the double probe pH meter results.