0476). We also detected five erbB2 mutations all in the non-smokers.

All of these mutations existed exclusively. The erbB2 gene mutations were predominantly found in non-smokers with adenocarcinomas. However, the completely exclusive mutation status could help us design individually tailored targeted molecular therapy for lung cancer.”
“A recombinant Saccharomyces cerevisiae displaying Candida antarctica lipase B (CALB) on the cell surface was constructed and used as a whole-cell biocatalyst to catalyze the esterification SC79 molecular weight of hexanoic acid and ethanol for the preparation of ethyl hexanoate, a fragrance compound of liquor. Various reaction parameters affecting the esterification catalyzed by CALB-displaying S. cerevisiae whole-cells were investigated. The optimal reaction conditions were reaction temperature 40 degrees C, hexanoic acid concentration 0.2 M, the ratio of hexanoic acid to ethanol 1:1.25 and the amount of cells 60g/l (17 U/g-dry cell). Molecular sieves AZD5153 (3 angstrom) were added to the reaction medium as the water absorbent. The yield reached 98.2% after reaction for 12 h under the optimal conditions. The CALB-displaying S. cerevisiae whole-cell biocatalyst exhibited quite a good operational

stability in the esterification, and more than 95% of its original activity was retained after 10 batches reaction. Thus, CALB-displaying S. cerevisiae whole-cell biocatalyst is promising for esters synthesis in non-aqueous phase. (c) 2009 Elsevier B.V. All rights reserved.”
“Background:\n\nThere is lack of knowledge to what degree clinical/morphological presentation

and course of IgA nephropathy (IgAN) prior to end-stage renal disease are risk factors for graft loss after kidney transplantation.\n\nMaterial and Methods:\n\nPatients with IgAN between 1988 and 2006 (registered in the Norwegian Kidney Biopsy Registry) CHIR-99021 in vitro who later received a kidney transplant (registered in the Norwegian Renal Registry) were included. The cohort was followed up regarding death-censored graft loss throughout 2008. Graft survival with a rapid progressive (RP) vs. a slow progressive (SP) course of pre-Tx IgAN (annual GFR > or < 30 mL/min/1.73 m2) was studied.\n\nResults:\n\nAmong 106 included patients, there were 14 graft losses giving a graft loss rate of 1.9/100 patient years. Follow-up until the first kidney transplant was 6.9 +/- 4.4 (range 0.1-19) yr. Patients with pre-Tx RP had a higher graft loss rate compared with SP patients (6.3 vs.1.3/100 patient years, p < 0.001). Graft loss rate with living-related donor (LRD) was similar to unrelated donor (UD) grafts. Most RP patients had received LRD grafts, and in SP patients, graft survival with LRD grafts was better than UD grafts (0.3 vs.2.1/100 patient years, p = 0.055).\n\nConclusions:\n\nA rapid pre-transplant course is a strong risk factor for transplant failure in patients with IgAN.”
“A simple consortium consisted of two members of Klebsiella sp.