57 ± 0.01, CVC+; 0.50 ± 0.02, p < 0.005) and ICW (CVC-; 19.5 ± 0.48, CVC+; 16.7 ± 0.42, p < 0.0001) were significantly Ganetespib lower than in CVC- group, ECW (CVC-; 14.5 ± 0.98, CVC+; 20.0 ± 0.60, p < 0.0001) and ECW/TCW (CVC-; 46.3 ± 0.81, CVC+; 53.0 ± 0.74, p < 0.0001) were significantly higher than in CVC- group. In CVC- group, BNP (r = 0.2943, p < 0.05) and CTR (r = 0.5343, p < 0.0001) showed a significant correlation with quantity of ultrafiltration, but there

were no correlation with ultrafiltration quantity in CVC+ group (BNP; r = 0.0297, NS, CTR; r = −0.0263, NS). Conclusions: Measurements of bioelectrical impedance and ultrasonic inferior vena cava diameter are quick, easy non-invasive methods to estimate body composition in bedside. ECW and ECW/TBW reflect the circulating blood volume, especially include interstitial fluid. This study demonstrated that CI, ECW and ECW/TBW are useful marker to assess appropriate quantity of ultrafiltration in the hemodialysis introduction patients with cardiovascular Selleck Dasatinib complications. LEE YUEH-TING, SU SHU-FEN, LEE CHIEN-TE, CHEN JIN-BOR Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Introduction: High prevalence of comorbidities has been reported in dialysis patients and comorbidities are associated with increased morbidity and mortality.

Although comorbidity index is commonly measured, the influence of comorbidity risk upon

dialysis adequacy and cardiac dilatation, however, has rarely been investigated. Methods: We undertook a cross-sectional study to analyze the influence of comorbidities measured by Charlson Comorbidity Index (CCI) upon dialysis adequacy presented by Kt/V Urea values and cardiac dilatation evaluated by index of cardiothoracic ratio of chest X ray after dialysis at an academic medical center in southern Taiwan. The clinical and biochemical data of these patients were retrospectively reviewed and collected. Results: A total of 871 hemodialysis patients were enrolled. The mean CCI score of all subjects was 3.6 ± 1.8. The spot prevalence of dialysis inadequacy (Kt/V < 1.2) and cardiac dilatation (cardiothoracic ratio > 0.5) both significantly increased steadily with higher comorbidities according to stratification of CCI score. Casein kinase 1 Meanwhile, the subjects in dialysis inadequacy or cardiac dilatation group had greater mean CCI score than the subjects in dialysis adequacy or non-cardiac dilatation group (4.2 ± 1.9 vs. 3.4 ± 1.7; 4.0 ± 2.0 vs. 3.4 ± 1.6; respectively, both P < 0.0001). Logistic regression analysis revealed that CCI score was an independent predictor for the dialysis adequacy and cardiac dilatation (OR: 0.812, P < 0.0001; OR: 1.141, P = 0.003, respectively). Conclusion: We concluded that comorbidity by using CCI score was predictive of dialysis adequacy and cardiac dilatation in hemodialysis patients.