83). The study did not find a significant effect of the exercise intervention on falls, although clinically relevant effects in either direction were not excluded by the study (incidence rate ratio = 1.15, 95% CI 0.82 to 1.61). The successful home safety aspect of the study is described in a separate paper.29

Kovács and colleagues23 used medical records and nursing documentation during the 6-month study period to collect falls data and reported that the risk for falls was reduced by 46% in the intervention group, but the difference did not reach statistical significance (relative risk = 0.54, 95% CI 0.29 to 1.01). This trial found a significant between-group difference in the mean length of time to first fall in favour of the intervention group (p = 0.049). The mean length of time to first fall was 18.5 weeks (95% CI 15.4 to 21.7) for the intervention group and 14.8 weeks Wortmannin concentration (95% CI 11.1 to 18.4) for the control group. As acknowledged by the authors, these results need to be treated with caution due to the small sample size (n = 41). Cheung and colleagues 22 reported no falls in either group during the three-month study period (n = 50), but did not state how the data were collected. The Tai Chi trial by Chen and colleagues 21 did not collect falls data. Due to the differences in settings and follow-up periods

a meta-analysis for the falls outcome was not undertaken. This systematic review found few studies of mixed quality in this vulnerable population. There was only one community-based trial among older adults with visual impairments.20 It had falls as the primary outcome and it found a protective buy Everolimus effect of home modification but not exercise. Data from

three small trials in residential care settings,21, 22 and 23 one of which specialised in people with visual impairment,23 indicated that multimodal exercise programs and Tai Chi can improve balance and physical function, and thus may reduce fall risk. This provides a rationale for future larger trials of physical interventions in this population that would measure actual fall rates, given the known effect of visual impairment as an intrinsic risk factor for falls, Resminostat and its subsequent negative effect on physical function. In the meta-analyses, although both outcome measures were in a direction favouring the intervention, only the Berg Balance Scale reached significance. The Timed Up and Go Test is widely used, but it may not be the most appropriate measure for adults with a visual impairment. It is possible that there is a limit to how much it can be expected that walking speed will increase, given the visual impairment, regardless of the level of physical improvement that the intervention provides. A study of sighted and visually impaired adults, matched for age and gender, found that sighted adults responded faster than those with visual impairments on the Timed Up and Go test and concluded that adults with visual impairments have difficulty with fast-paced movements.