9 at a mean of 2.88 months after addition of lercanidipine/enalapril, although the difference from baseline was not statistically significant (p = 0.321). Fig. 3 Therapeutic profile before (baseline) and after adding lercanidipine/enalapril 10/20 mg fixed-dose combination. ACEI angiotensin-converting enzyme inhibitor, ARAII angiotensin II receptor antagonist, CCB calcium channel blocker, FDC fixed-dose combination, RI renin inhibitor 3.4 Tolerability Treatment with lercanidipine/enalapril was well tolerated. Treatment-emergent adverse effects occurred in only one patient (0.3 %), who developed a persistent dry cough after the initiation of lercanidipine/enalapril treatment. This cough was considered to be possibly

related to treatment with enalapril. None of the patients developed edema. 4 Discussion This observational registry study showed that treatment with a lercanidipine/enalapril FDC was associated with significant AG-881 chemical structure reductions in SBP selleck products and DBP and a significant increase in the proportion of patients achieving BP control compared with baseline. The reduction in BP observed in our study was as expected with combinations of two or more antihypertensive drugs. A meta-analysis 3-Methyladenine nmr by Law et al. [11] found that the use of two antihypertensive drugs at half-standard doses produced reductions in SBP and DBP of 13.3 and 7.3 mmHg, respectively;

corresponding values for three drugs at half-standard doses were 19.9 and 10.7 mmHg, respectively11. Our results are also in agreement with the well known efficacy of an FDC of a CCB with a modulator of the RAS [20], even if we consider the relatively old population evaluated, and the extended period of treatment between diagnosis and inclusion in this study. In this context, the rate of Pregnenolone BP control was also impressive, being observed in 51 % of patients with BP <140/90 mmHg after a mean of 2.88 months of treatment with the fixed-dose regimen. In randomized, controlled phase III trials of lercanidipine/enalapril FDC, reductions in SBP and DBP of

7.7–9.8 and 7.1–9.2 mmHg, respectively, were observed after 12 weeks of treatment [21]. The reductions in SBP and DBP observed in our study were greater than this (18.08 and 10.10 mmHg, respectively). In these two studies, the proportion of patients with normalized SBP and DBP was 22–24 % [21]. It should be noted that these studies included only patients who had not achieved BP control with either lercanidipine or enalapril as monotherapy, and this could have contributed to the smaller reductions in BP and lower BP control rates compared with our study. Furthermore, one of these studies used a lower dose of enalapril (10 mg) than in our study and produced smaller reductions in SBP and DBP than seen with lercanidipine/enalapril 10/20 mg in the second study. It should also be noted that the patients included in our registry had been receiving antihypertensive regimens prescribed by general practitioners rather than specialists.