All participants completed a questionnaire regarding socio-demographic and lifestyle factors. Risk factor analyses were carried out using logistic regression models.
RESULTS: Factors associated with TB were Inuit ethnicity, living in a small settlement, unemployment,
no access to tap water, no bathroom or flushing toilet, underweight, smoking, frequent intake of alcohol and immunosuppressive treatment. The multivariate model showed that Inuit ethnicity (OR 15.3), living in a settlement (OR 5.1), being unemployed (OR 4.1) and frequent alcohol use (OR 3.1) were independent determinants of risk. Unemployment was associated with the highest population-attributable risk (29%).
CONCLUSION: Risk factors associated with
living in a settlement should be further explored and an investigation of genetic susceptibility is warranted.”
“Leptoderris fasciculata (Benth.) Dunn is a woody R428 inhibitor liana that grows in the tropical zone of West Africa, where it is exploited in traditional medicine for a number of uses. In the south-eastern Ivory Coast, it is applied to stop bleeding in women after childbirth or in cases of menorrhagia. The phytochemistry of this plant has received little previous attention. We report the isolation of 40,5,6,7-tetramethoxyisoflavone and dihydrochalcone, new as natural products, together with 10 known compounds from the leaves of L. fasciculata collected in the Ivory Coast. (C) 4-Hydroxytamoxifen datasheet 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.”
“OBJECTIVE: To measure the tuberculosis (TB) incidence rate and assess the relative risk of TB disease in contacts based on the tuberculin skin test (TST) and sputum status of index cases.
DESIGN: All contacts aged < 20 years who were exposed to a TB case in 2005 were Cell Cycle inhibitor cross-matched using an electronic surveillance system to estimate TB incidence over a 24-month follow-up period.
RESULTS: Among 6959 contacts there were 67 secondary cases (1%). The
incidence was highest in the first year after exposure and decreased by half in the second year (P = 0.001). The relative risks of developing TB in contacts aged 0-4, 5-9, 10-14 and 15-19 years were respectively 325, 209, 337 and 53 times greater than for the general population. The hazard ratio of developing TB among contacts with a TST >= 15 mm induration was 12 times higher than for those with a TST < 5 mm (P = 0.003).
CONCLUSIONS: The relative risk of developing TB disease within 24 months of exposure was approximately 200-300 times greater for contacts aged < 15 years. The majority developed TB within 12 months of exposure.”
“A novel dihydronaphthalenone, phomonaphthalenone A (1) was isolated from solid cultures of the endophytic fungus Phomopsis sp. HCCB04730, together with six known naphthoquinones (2-7). The structure of 1 was elucidated through spectroscopic and X-ray crystallographic analysis.