CB: Professor

at the Department of Genetics AZD9291 solubility dmso and Biotechnology, Faculty of Proteases inhibitor Agricultural Sciences, University of Aarhus, Denmark. AR: Professor at the Laboratory of Surgical Research, Institute of Clinical Medicine, University of Tromsø, Norway. Acknowledgements The assistance of veterinarians Hege Hasvold and Siri Knudsen, and technicians Ragnhils Osnes and Hege Hagerup is highly acknowledged. Peter Sørensen is acknowledged for his support to the analysis of the microarray data. This study was supported by a grant from the Northern Norway Regional Health Authority (Helse Nord RHF). References 1. Arai M, Yokosuka O, Chiba T, Imazeki F, Kato M, Hashida J, Ueda Y, Sugano S, Hashimoto K, Saisho H, Takiguchi M, Seki N: Gene expression profiling reveals the mechanism and pathophysiology of

mouse liver GANT61 research buy regeneration. J Biol Chem 2003, 278:29813–29818.PubMedCrossRef 2. Fukuhara Y, Hirasawa A, Li XK, Kawasaki M, Fujino M, Funeshima N, Katsuma S, Shiojima S, Yamada M, Okuyama T, Suzuki S, Tsujimoto G: Gene expression profile in the regenerating rat liver after partial hepatectomy. J Hepatol 2003, 38:784–792.PubMedCrossRef 3. Locker J, Tian JM, Carver R, Concas D, Cossu C, Ledda-Columbano GM, Columbano A: A common set of immediate-early response genes in liver regeneration and hyperplasia. Hepatology 2003, 38:314–325.PubMedCrossRef 4. Su AI, Guidotti LG, Pezacki JP, Chisari FV, Schultz PG: Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci USA 2002, 99:11181–11186.PubMedCrossRef 5. White P, Brestelli JE, Kaestner KH, Greenbaum LE: Identification of transcriptional networks during liver regeneration. J Biol Chem 2005, 280:3715–3722.PubMedCrossRef 6. Taub R: Liver regeneration: From myth to mechanism. Nat Rev Mol Cell Biol 2004, 5:836–847.PubMedCrossRef P-type ATPase 7. Fujiyoshi M, Ozaki M: Molecular mechanisms of liver regeneration

and protection for treatment of liver dysfunction and diseases. J Hepatobiliary Pancreat Sci 2011, 18:13–22.PubMedCrossRef 8. Koniaris LG, McKillop IH, Schwartz SI, Zimmers TA: Liver regeneration. J Am Coll Surg 2003, 197:634–659.PubMedCrossRef 9. Campbell JS, Prichard L, Schaper F, Schmitz J, Stephenson-Famy A, Rosenfeld ME, Argast GM, Heinrich PC, Fausto N: Expression of suppressors of cytokine signaling during liver regeneration. J Clin Invest 2001, 107:1285–1292.PubMedCrossRef 10. Aldeguer X, Debonera F, Shaked A, Krasinkas AM, Gelman AE, Que XG, Zamir GA, Hiroyasu S, Kovalovich KK, Taub R, Olthoff KM: Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration. Hepatology 2002, 35:40–48.PubMedCrossRef 11. Debonera F, Aldeguer X, Shen XD, Gelman AE, Gao F, Que XY, Greenbaum LE, Furth EE, Taub R, Olthoff KM: Activation of interleukin-6/STAT3 and liver regeneration following transplantation. J Surg Res 2001, 96:289–295.