During the implantation of a cardiac resynchronization therapy (CRT) device, acute impedance curves were recorded along with stroke volume determined by the arterial pulse contour method. In an overdrive protocol, the impedance parameter “”stroke URMC-099 chemical structure impedance”" decreased in significant correlation with stroke volume in all patients. The median correlation coefficient between stroke volume and stroke impedance was 0.83 (interquartile range 0.70-0.89). Furthermore, the atrioventricular delay was optimized based on impedance and reference stroke volume. After optimization by the impedance method, it differed by 18 +/- 15 ms from the figure after optimization by the invasive reference. Compared

with a standard atrioventricular delay of 120 ms, stroke volume was improved by 8.6 +/- 9.8% with the use of invasive optimization and by 6.4 +/- 10.8% with the use of impedance-based optimization.

Conclusions: In CRT patients with chronic infarction and wall motion abnormalities,

impedance is a valid parameter to estimate stroke volume and to guide optimization of CRT timing.”
“Electrical transport properties in ferromagnetic shape memory Ni-Mn-Ga single crystal have been investigated both in experiment Alvocidib and theory by analyzing electrical resistivity along different crystallographic directions during heating. The experimental results show a clear first-order martensitic transformation and a large anisotropic resistivity

(AR) of 23.7% at the tetragonal martensitic phase. The theoretical conductivity (sigma=1/rho), estimated using first-principles calculations combined with classical Boltzman transport theory, proves essential crystallographic anisotropic resistivity (AR=31%) in the martensitic phase and agrees well with experimental results. The AR in the martensitic phase is reveled to mainly originate from the splitting of the minority-spin Ni 3d and Ga 4p states near the Fermi level and hence reconstruction of the minority-spin Fermi surface upon martensitic transformation. (C) 2010 American Institute of Physics. [doi:10.1063/1.3354105]“
“Within the framework of a series of studies mandated by the Ministry of Public Health of Cameroon to obtain baseline data for an epilepsy education Pevonedistat program adapted to our communities, we interviewed 456 subjects without epilepsy in the Ebolowa Regional and Sangmelima District Hospitals. We found that 99.6 and 72.6% had heard or knew a person or people with epilepsy (PWE) and 76.8% had seen a seizure. About 58% of respondents would offer equal employment opportunities to PWE; 39.6% and 33.6% would respectively object to their children associating with OF marrying PWE; 13% associated epilepsy with insanity and witchcraft, whereas 82.5% would recommend modern treatment for epilepsy. Predictors of negative attitudes were the beliefs that epilepsy is hereditary (26.3%) and epilepsy is a form of insanity (13%).