Factors that influence these variations are differences in social security arrangements for Peptide 17 mouse occupational diseases, in diagnostic criteria and in guidelines for reporting. (Nordman et al. 1999; Coggon 2001; Karjalainen

and Niederlaender 2004; Rosenman et al. 2006). Under-recognition and under-reporting of occupational diseases starts with workers. Research based on surveys of employees has described under-reporting of occupational diseases of more than 60% across different industrial sectors and jobs (Biddle et al. 1998; Pransky et al. 1999; Scherzer et al. 2005). Workers share often the same reasons for not reporting: fear of retribution by the employer, concern about supervisors’ opinion, lack of knowledge on the reporting and compensating system and feeling that symptoms are not serious enough (Rosenman et al. 2000; Azaroff et al. 2002; Galizzi et al. XAV-939 2006). If a worker with symptoms visits a doctor, the work relatedness may not be considered for some time, delaying the diagnosis of, i.e., occupational asthma for several years (Poonai et al. 2005). If (occupational) physicians are insecure about their diagnosis they might not report it. Administrative barriers, lack of adverse consequences for under-reporting and the absence of positive reinforcement for reporting may also contribute to the problem (Pransky et al. 1999; Blandin et al. 2002). Similar problems

and barriers are described in other registries like the from reporting of infectious diseases (Silk

and Berkelman GSK621 cell line 2005; Friedman et al. 2006) or adverse drug reactions (Bäckström et al. 2004; Vallano et al. 2005; Hazell and Shakir 2006). In the Netherlands, both occupational physicians (OPs) and occupational health services (OHS) are obliged to report occupational diseases to the Netherlands Center for Occupational Diseases (NCOD) for preventive reasons. Since this is no workers’ compensation system, there is no financial compensation for reported occupational diseases. In this national registry, there has been considerable under-reporting over the years. Dutch OPs mentioned several reasons for not reporting: lack of time, uncertainty about work as a causal factor for a specific disease, lack of awareness of the requirements for reporting, disagreement about the criteria to determine a work-relation, (alleged) legal objections and lack of motivation to report. (Lenderink 2005; de Vos and Nieuwenhuijsen 2006). Several interventions to improve the reporting behaviour of physicians are proposed and sometimes tested. There is some evidence that keeping in close contact with reporters, user-friendly reporting systems, assured confidentiality, education, regular contact, provision of feedback information, accreditation points for continuing education or a small fee might improve reporting. (Hazell and Shakir 2006; Orriols et al.