It could be very likely that bisphosphonates were started after a fracture occurred and this is probably the reason is why we did not find a protective effect of bisphosphonates for example. In conclusion, in our study we found a high incidence rate of vertebral and non-vertebral fracture
rates during a follow-up of 5 years in patients with buy CBL-0137 established RA compared to the general population. Conflicts of interest None. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. References 1. Haugeberg G, Uhlig T, Falch JA et al (2000) Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Selleck GSK690693 arthritis register. Arthritis Rheum 43:522–530PubMedCrossRef 2. Lems WF, Dijkmans BA (1998) Should we look for osteoporosis in patients with rheumatoid arthritis? Ann Rheum Dis 57:325–327PubMedCrossRef 3. Cooper C, Coupland C, Mitchell M (2000) Rheumatoid arthritis, corticosteroid therapy and hip fracture. Ann Rheum Dis 54:49–52CrossRef 4. van Staa TP, Geusens P, Bijlsma JW et al (2006) Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum 54:3104–3112PubMedCrossRef 5. Ørstavik RE, Haugeberg G, Mowinckel P et al (2004) Vertebral
deformities in rheumatoid arthritis: a comparison with population-based controls. Arch Intern Med 23:420–425CrossRef
6. Burger H, Van Daele PLA, Algra D et al (1994) Vertebral selleck deformities as predictors of non-vertebral fractures. BMJ 309:991–992PubMed 7. Lindsay R, Silverman SL, Cooper C et al (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285:320–323PubMedCrossRef 8. Lodder MC, Haugeberg G, Lems WF et al (2003) Radiographic damage associated with Demeclocycline low bone mineral density and vertebral deformities in rheumatoid arthritis: the Oslo–Truro–Amsterdam (OSTRA) collaborative study. Oslo–Truro–Amsterdam (OSTRA) Collaborative Study. Arthritis Rheum 49:209–215PubMedCrossRef 9. Arnett FC, Edworthy SM, Bloch DA et al (1998) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324CrossRef 10. Fries JF, Spitz P, Kraines RG et al (1980) Measurement of patient outcome in arthritis. Arthritis Rheum 23:137–145PubMedCrossRef 11. van Gestel AM, Prevoo ML, t Hof MA et al (1996) Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria. Arthritis Rheum 39:34–40PubMedCrossRef 12. Genant HK, Wu CY, van Kuijk C et al (1993) Vertebral fracture assessment using a semiquantitative technique.