(C) 2012 Elsevier Editora Ltda. All rights reserved.”
“Background: Erythropoietin (EPO) and granulocyte colony stimulating factor SHP099 supplier (GCSF) are potential novel therapies after myocardial infarction (MI) We first established the optimal and clinically applicable dosages of these drugs in mobilizing hematopoietic stem

cells (HSC), and then tested the efficacy of monotherapy and combination therapy post-MI.

Methods and Results: Optimal doses were established in enhanced green fluorescent protein (eGFP) + chimeric mice (n = 30). Next, mice underwent MI and randomized into 4 groups (n = 18/group) 1) GCSF: 2) EPO; 3) EPO+GCSF; and 4) control Left ventricular (LV) function was analyzed pre-MI, at 4 hours and at 28 days post-MI Histological assessment of infarct size, blood vessels, apoptotic cardiomyocytes, and engraftment of eGFP+ mobilized cells were analyzed at day 28 selleck LV function in the control group continued to deteriorate, whereas all treatments showed stabilization The treatment groups resulted in less scarring, increased numbers of mobilized cells to the infarct border zone (BZ), and a reduction in the number of apoptotic cardiomyocytes. Both EPO groups had significantly more capillaries and arterioles at the BZ

Conclusion: We have established the optimal doses for EPO and GCSF in mobilizing FISC from the bone marrow and demonstrated that therapy

with these agents, either as monotherapy or combination therapy, led to Improvement of cardiac function post-MI Combination therapy does not seem to have additive benefit over monotherapy in this model (J Cardiac Fail 2010,16 669-678)”
“In Brazil, bats have been assigned an increasing importance in public health as they are important rabies reservoirs. Phylogenetic studies have shown that rabies virus (RABV) strains from frugivorous bats Artibeus spp. are closely associated to those from the vampire

bat Desmodus rotundus, PF-00299804 ic50 but little is known about the molecular diversity of RABV in Artibeus spp. The N and G genes of RABV isolated from Artibeus spp. and cattle infected by D. rotundus were sequenced, and phylogenetic trees were constructed. The N gene nucleotides tree showed three clusters: one for D. rotundus and two for Artibeus spp. Regarding putative N amino acid-trees, two clusters were formed, one for D. rotundus and another for Artibeus spp. RABV G gene phylogeny supported the distinction between D. rotundus and Artibeus spp. strains. These results show the intricate host relationship of RABV’s evolutionary history, and are invaluable for the determination of RABV infection sources. (C) 2012 Elsevier Editora Ltda. All rights reserved.”
“Background: Studies have suggested some benefit of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors in congestive heart failure (CHF).