HCC is one of the most common fatal cancers worldwide, and the incidence of HCC in many countries is increasing in parallel to an increase in chronic HBV infection. Because the role of HBV infection and the pathogenic mechanisms of the cancer-causing variant are not Selleckchem JIB04 entirely clear, there is still a lack of effective treatment of HCC. For an in-depth review and

understanding of these interactions, click here to enhance insight into HBV replication and pathogenesis on a cellular level, we catalogued all published interactions between HBV and human proteins, particularly human proteins associated with HCC. We have provided a general overview of the landscape of human proteins that interact with HBV. Acknowledgements This study was funded by grants from the National Natural Science Foundation of China (NSFC NO. 30772055) and sponsored by Shanghai Postdoctoral VX-770 concentration Scientific Program. Electronic supplementary material Additional file 1: Additional Tables. Table S1. Total interactions between HBV and human proteins catalogued from related literature. The meaning of each is as follows: Pubmed_ID:

PubMed article ID. HBV_gene_mention: HBV gene name appeared in the sentence. HBV_gene: the HBV gene after standardization. verb_mention: the meaning of the verb or verb noun such as heavier appeared in the sentence. verb: the verb after standardization. human_gene_mention: human gene names appeared in the sentence. human_official_gene_symbol: the human gene after standardization. human_gene_entrez_ID: standardization of the ID of the human gene. human_official_gene_description: standardization of the description of the human gene. sentence: the key sentence. PubMed_link: PubMed abstract link. Additional file PD184352 (CI-1040) 1, Table S2. Listing and Distribution of Keywords Associated with the HBV Human Protein Interaction Database. Statistical analysis of interaction verb and calculation of the proportion of each verb. Additional file 1, Table S3. Listing

of human proteins interacting with more than one viral protein. Additional file 1, Table S4. Listing of HHBV-HHBV protein- protein interactions. Interacting human proteins are referenced with their cognate NCBI gene name (columns 1 and 2). These physical and direct binary protein-protein interactions were retrieved from the BIND, BioGRID, DIP, GeneRIF, HPRD, IntAct, MINT, and Reactome databases. Interaction type (6 = KEGG database,7 = text mining,8 = homology). Additional file 1, Table S5. Hepatocellular carcinoma-associated proteins (HHCC) catalogued from related literature. Additional file 1, Table S6. Listing of HHBV- HHCC. HHBV: HBV-interacting proteins. HHCC: liver cancer-related genes. HHBV- HHCC: overlap. Additional file 1, Table S7A. Distribution of cellular component Gene Ontology terms associated with HBV-human protein interactions. Additional file 1, Table S7B.