Marianna University School of Medicine; 2Department of Nephrology, Nagoya University Graduate School of Medicine;

3Center for Clinical Epidemiology, St. Luke’s Life Science Institute, St. Luke’s International Hospital; 4Division of Kidney & Hypertension, The Jikei University School of Medicine Introduction: We have started the Nationwide Retrospective Cohort Study in IgA nephropathy in Japan to clarify the suitable choice of treatment in IgA nephropathy patients with a variety of clinical presentation. We evaluated in this interim analysis the therapeutic efficacy on the renal outcome defined as p38 MAP Kinase pathway 50 percent increase in the serum creatinine concentration from baseline between four kinds of therapies; conservative therapy without steroids, oral steroids, intravenous pulse methylprednisolone followed by oral steroids (pulse methylprednisolone alone), and tonsillectomy in combination with pulse methylprednisolone Alisertib mw (tonsillectomy with pulse methylprednisolone). Methods: Adult

patients with IgA nephropathy diagnosed by the first renal biopsy during the three years from 2002 to 2004 were eligible. Data at the time of renal biopsy and during the follow-up were collected, and total 1,175 cases from 42 facilities were registered. Among them, we analyzed 1082 cases with sufficient data for the analysis by this interim analysis. Results: The median observation period was 5.4 years. Janus kinase (JAK) The number of patients treated with each therapy were as follow; conservative therapy 534 (49.4%), oral steroids 208 (19.2%), pulse methylprednisolone alone 123 (11.4%), and tonsillectomy with pulse methylprednisolone 217 (20.1%). In this period, 114 patients reached the renal outcome. Kaplan-Meyer survival analysis revealed the best renal prognosis in the patients with tonsillectomy with pulse methylprednisolone. Cox regression analyses with adjustment for baseline covariates showed that, compared to the patients with tonsillectomy with pulse methylprednisolone, the risk of the renal outcome for

those with other therapy was as follow; conservative therapy 4.00 (95% CI, 1.58–10.13), oral steroids 1.66 (0.60–4.56), pulse methylprednisolone alone 3.28 (1.20–8.96). Conclusion: This interim analysis indicates the superiority of tonsillectomy with pulse methylprednisolone in terms of improving renal prognosis among the whole patients studied. After data cleaning of all cases, we will clarify proper choice of therapy in patients with IgA nephropathy according to their clinical presentation. YASUDA YOSHINARI1, YASUDA TAKASHI2, OHDE SACHIKO3, TAKAHASHI OSAMU3, KAWAMURA TETSUYA4, MATSUO SEIICHI1 1Nephrology/CKD Initiatives, Nagoya University; 2Nephrology & Hypertension, St. Marianna University; 3Center for Clinical Epidemiology, St.