\n\nConclusion: Our data suggest that EIF4G1 can serve as a biomarker for the prognosis of NPC patients.”
“Despite major advances in breast cancer therapy, annual mortality remains significant with a sizeable proportion of patients eventually succumbing to metastatic disease. Clearly, optimizing approaches for identification and management of women at heightened risk for breast cancer will reduce overall morbidity and mortality from the disease. Over the past few decades, advances in molecular genetics and linkage analyses have allowed for the identification of specific germline mutations underlying a significant fraction of hereditary breast cancer. Genome-wide association
studies have been developed as a powerful tool in identifying lower PF-562271 cell line penetrance mutations, and it is believed that such genome-level variations may act in concert to give rise to the majority of inherited breast cancer risk. Controversies and uncertainties remain in clinical application of newly identified selleck chemicals llc genomic loci that confer genetic susceptibility. This article reviews the well-characterized breast cancer susceptibility genes, highlights recent publications pertaining to the less well known and lower penetrance genetic polymorphisms, summarizes challenges in translating research findings to the clinical scenario, and offers some recommendations for clinical practice.”
studies have demonstrated an association between sleep duration and obesity, but few population-based studies have examined the association. We examined the relationship between recent and usual lifetime sleep duration with the odds of obesity in 5549 women that participated in a population-based
telephone survey.\n\nMethods: The structured telephone interview included questions Dibutyryl-cAMP purchase on usual sleep duration in adult life and the recent past, as well as height and weight and other demographic and lifestyle characteristics. We examined odds of overweight (BMI: 25-29.9 kg/m(2)), obesity (BMI: 30-39.9 kg/m(2)) and extreme obesity (BMI: 40 kg/m(2)) according to reported sleep duration.\n\nResults: Compared to women who slept 7-7.9 h per night, women who slept an average of <6 h per night in the recent past had significantly greater odds of obesity (Odds Ratio [OR]: 1.89; 95% Confidence Interval [Cl]: 1.45-2.47) and extreme obesity (OR: 3.12; Cl: 1.70-5.75), adjusting for potential confounding factors. Weaker associations were noted for short lifetime sleep duration. Current short sleep (<7 h) was associated with greater odds of obesity (>= 30 kg/m2) in those reporting less than 7 h (OR: 1.59; 95% Cl: 0.93-2.78) and in those reporting 8 or more hours (OR: 1.75; 95% Cl: 1.33-2.32) of sleep throughout adult life.\n\nConclusions: Current short sleepers were more likely to be obese regardless of their usual sleep duration earlier in life.